DNA was extracted from blood samples of all participants and MSRE-PCR and real-time PCR were used for quantification of CpG methylation alterations. This is the first study to investigate DOK7 CpG hypermethylation in blood leukocytes of 31 TR (ER+) BC compared to 29 tamoxifen sensitive BC to evaluate DOK7 as a potential TR biomarker. The epigenetic alteration that happens by hypermethylation of tumor suppressor genes and hypomethylation of oncogenes has been suggested to be useful in early cancer or drug resistance diagnosis. Hence, TR early detection reduces BC recurrence and fatalities. Tamoxifen drug is the first line therapy for BC however tamoxifen resistance (TR) has shown in 30–50% of cases that may face BC recurrence. Memo entry in Registry of Obligations and Allotments.Breast cancer (BC) is among the most common cause of cancer 10.4% and one of the leading causes of death among 20–50 years old women in the world. Memo entry in the Registry of Obligations and Allotments.Ĭash – National Treasury – MDS Subsidy income from national government Office building Construction in progress – OPI Life and retirement contribution Pag-ibig contribution Philhealth contribution Cash – National Treasury – MDSĮlectricity Telephone expense – Landline Accounts payable Due to BIR Cash – National Treasury – MDSĭue to BIR Subsidy income from national governmentĬash – Collecting Officer Sales revenue Permit fees Miscellaneous incomeĬash in Bank – Local currency – Current account Cash – Collecting OfficerĪdvances to contractor Cash – National Treasury – MDSĬonstruction in progress – Other Public Infrastructure Advances to contractor Accounts payableĪccounts payable Due to BIR Cash – National Treasury – MDSĬonstruction in progress – Other Public Infrastructure Accounts payableĪccounts payable Due to BIR Cash – National Treasuryĭue to BIR Subsidy income from national government Office Building Construction in progress – OPIĢ40 240 160 40 120 400 40 360 80 80 800 800Ĭonstruction materials inventory Accounts payableĬonstruction in progress – Other Public Infrastructure Construction materials inventoryĬonstruction in progress – Other Public Infrastructure Due to BIR Cash – Disbursing Officerĭue to BIR Cash – National Treasury – MDS Salaries and wages – Regular Personal economic relief allowance (PERA) Additional compensation Due to BIR Due to GSIS Due to Pag-ibig Due to Philhealth Cash – Disbursing Officerĭue to GSIS Due to Pag-ibig Due to Philhealth Cash – National Treasury – MDS

Memo entry in the RAOPS, RAOMO, RAOCO and RAOFE.Ĭash – National Treasury – MDS Subsidy Income from National GovernmentĬash – Disbursing Officer Cash – National Treasury – MDS A Excess of income over expenses Depreciation Increase in due from national government agencies Increase in prepaid rent Increase in accounts payable Cash provided by operating activities

Advanced accounting 2 guerrero 2017